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KMID : 0617219970080010069
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Duksung Bulletin Phamaceutical Sciences
1997 Volume.8 No. 1 p.69 ~ p.71
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Evaluation for Intrinsic Skin Permeation of Unstable Compounds
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Lee Ch´o Ae-Ri
Kakuji Tojo
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Abstract
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An evaluation method is proposed for the intrinsic skin permeation rate of unstable compounds. Vitamin C and vitamin E were used as the model compounds. The degradation of vitamin C and E in the solutions followed first-order kinetics with degradation constants of 0.26h^-1 and 0.014h^-1, respectively. The apparent skin permeation profiles of vitamin C and E in vitro, approximated by a nonlinear profile of the polynomial regression method, was corrected for intrinsic permeation rate considering first-order degradation in the receptor solution. The intrinsic profiles evaluated agreed well with the ones determined from radio-labelled compounds, indicatingthe feasibility of the present analysis.
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